Self-Worth and Engaging in Detrimental Behaviour

I've long felt that some people engage in unskillful behaviour as a consequence of not valuing themselves. For example, they engage in drugs to numb or detrimental sexuality, seemingly because they feel unworthy or undeserving. **Would Buddhism link such a behaviour to self-compassion or self-esteem? Is there such a thing in Buddhism as instincts of self-harm?** Or, even, can such self-impeding behaviour be linked to some other cause, such as not seeing the consequence of actions or something of the like? Thank you