How can we make sense of the Universe from the Buddhist perspective?

I know this is the kind of the question Buddha discouraged to ponder upon with the example of the poisonous arrow. But after 25 centuries, after what Newton and Einstien and Astronomers and Scientists have bought in light for us, the enormous size of our Universe. It is billions and billions of kilometers across, our earth is a small planet circling an average star which circles an ordinary galaxy on its periphery. Out in the outer space, there are billions of such galaxies and as far as we know its lifeless, or devoid of intelligent life, like us. And then there is empty space, huge empty space. The nothingness or emptiness of the universe. And then there is us. A miracle, what sets this question is the paradox of our complexity (biological) against the background of the emptiness of outer space. And here we have reached the conclusion of the first **noble truth of Dukkha**!!! **Looking at the star-filled night sky, as a Buddhist, how do I make sense of all this?**